Inflammation models include macrophages and possibly others cells (such as adipocytes). This allows effects of anti-inflammatory compounds measured. Stimulation of T cells by DC (DC-T cell interaction): bone marrow DC can be stimulated with protein followed by measuring the CD4 + T reaction.
- Poland M, Ten Klooster JP, Wang Z, Pieters R, Boekschoten M, Witkamp R, Meijerink J.
Docosahexaenoyl serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23-IL-17 signaling in macrophages.
Biochim Biophys Acta. 2016 Sep 20. pii: S1388-1981(16)30249-9. doi: 10.1016/j.bbalip.2016.09.012. [Epub ahead of print].